pentobarbital will reduce the level or result of pitolisant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Pitolisant exposure is lessened by 50% if coadministered with solid CYP3A4 inducers.pentobarbital will decrease the level or result of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metaboli